Membrane separation technology for extracting colistin sulfate

Sulfate colistin, also known as sulfate colistin, is produced by polymyxa and has strong antibacterial effects on Gram negative bacteria. It is used to treat intestinal diseases caused by Gram negative bacteria, as a feed additive, and has a significant growth promoting effect; It is also effective against Pseudomonas aeruginosa infections (sepsis, urinary tract infections, burn or wound infections). In recent years, the extraction of antibiotics has become one of the key areas for promoting membrane separation technology. Membrane separation technology can replace traditional separation and purification techniques, simplify the production process of antibiotics, improve product yield, and reduce environmental pollution.

After pretreatment of the sulfuric acid colistin fermentation broth using a combination membrane system and a fermentation broth softening system, the high valence alkaline compound of sulfuric acid colistin is utilized. Continuous ion exchange is carried out using methyl methacrylate or acrylic acid based resin, and sulfuric acid is used for analysis to obtain the product sulfuric acid colistin.

Advantages of sulfuric acid colistin membrane separation technology

1. Low temperature operation, no phase change or qualitative change, concentration process does not deepen the color of the solution, does not damage the effective ingredients, greatly saving energy consumption;;

2. The concentrated sulfuric acid colistin extraction liquid has a small volume, reduces resin consumption, improves production efficiency, and can remove a large amount of small molecule proteins, pigments, and salts while concentrating, purifying the product;

3. System cross flow operation design, no need to add filter aids, will not introduce new impurities, completely solving the problem of pollution blockage;

4. The automation level is high and safe, effectively reducing labor intensity. The membrane filtration process is carried out in a closed container, which can achieve clean production very well;

5. Made of 304 or 316L stainless steel material, in compliance with GMP and other certification standards.